Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages

Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus res...

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Bibliographic Details
Main Authors: Huaqiang Tao, Yunxia Tao, Chen Yang, Wenming Li, Wei Zhang, Xueyan Li, Ye Gu, Yujing Hong, Huilin Yang, Yu Liu, Xing Yang, Dechun Geng
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
Urolithin A
senile osteoporosis
osteoclast
autophagy
MAPK
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.875611/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.875611/full

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