Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages
Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus res...
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Bibliographic Details
| Main Authors: |
Huaqiang Tao,
Yunxia Tao,
Chen Yang,
Wenming Li,
Wei Zhang,
Xueyan Li,
Ye Gu,
Yujing Hong,
Huilin Yang,
Yu Liu,
Xing Yang,
Dechun Geng |
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| Format: | Article
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| Language: | English |
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| Published: |
Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology
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| Subjects: | |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.875611/full
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