Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages
Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus res...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.875611/full |
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| author | Huaqiang Tao Yunxia Tao Chen Yang Wenming Li Wei Zhang Xueyan Li Ye Gu Yujing Hong Huilin Yang Yu Liu Xing Yang Dechun Geng Dechun Geng |
| author_facet | Huaqiang Tao Yunxia Tao Chen Yang Wenming Li Wei Zhang Xueyan Li Ye Gu Yujing Hong Huilin Yang Yu Liu Xing Yang Dechun Geng Dechun Geng |
| author_sort | Huaqiang Tao |
| collection | DOAJ |
| description | Graphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus resulting in decreased osteoclast-related markers and bone loss. |
| first_indexed | 2024-04-14T05:03:42Z |
| format | Article |
| id | doaj.art-72755f4dbdd94f009e09e7e477bd0413 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-14T05:03:42Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-72755f4dbdd94f009e09e7e477bd04132022-12-22T02:10:50ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-05-011310.3389/fphar.2022.875611875611Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow MacrophagesHuaqiang Tao0Yunxia Tao1Chen Yang2Wenming Li3Wei Zhang4Xueyan Li5Ye Gu6Yujing Hong7Huilin Yang8Yu Liu9Xing Yang10Dechun Geng11Dechun Geng12Department of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaAnesthesiology Department, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Orthopedics, Changshu Hospital Affiliated to Soochow University, First People’s Hospital of Changshu City, Changshu, ChinaDepartment of Preventive Medicine, Nantong University, Nantong, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, Wuxi Ninth People’s Hospital Affiliated to Soochow University, Wuxi, ChinaOrthopedics and Sports Medicine Center, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Suzhou, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Soochow University, Suzhou, ChinaDepartment of Orthopedics, Changshu Hospital Affiliated to Soochow University, First People’s Hospital of Changshu City, Changshu, ChinaGraphical AbstractUro-A, which is a metabolite of intestinal flora and mainly produced from pomegranates and some nuts, suppresses osteoclast formation and bone resorption by activating autophagy. Uro-A upregulated the expression of Beclin 1 and LC3 and modulated bone homeostasis 4 in BMMs, thus resulting in decreased osteoclast-related markers and bone loss.https://www.frontiersin.org/articles/10.3389/fphar.2022.875611/fullUrolithin Asenile osteoporosisosteoclastautophagyMAPK |
| spellingShingle | Huaqiang Tao Yunxia Tao Chen Yang Wenming Li Wei Zhang Xueyan Li Ye Gu Yujing Hong Huilin Yang Yu Liu Xing Yang Dechun Geng Dechun Geng Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages Frontiers in Pharmacology Urolithin A senile osteoporosis osteoclast autophagy MAPK |
| title | Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages |
| title_full | Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages |
| title_fullStr | Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages |
| title_full_unstemmed | Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages |
| title_short | Gut Metabolite Urolithin A Inhibits Osteoclastogenesis and Senile Osteoporosis by Enhancing the Autophagy Capacity of Bone Marrow Macrophages |
| title_sort | gut metabolite urolithin a inhibits osteoclastogenesis and senile osteoporosis by enhancing the autophagy capacity of bone marrow macrophages |
| topic | Urolithin A senile osteoporosis osteoclast autophagy MAPK |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.875611/full |
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