Pharmacogenetics and Pharmacokinetics of Moxifloxacin in MDR-TB Patients in Indonesia: Analysis for <i>ABCB1</i> and <i>SLCO1B1</i>

Pharmacogenetics and Pharmacokinetics of Moxifloxacin in MDR-TB Patients in Indonesia: Analysis for <i>ABCB1</i> and <i>SLCO1B1</i>

<b>Background/Objectives</b>: Studies show that SNPs in <i>ABCB1</i> rs2032582 and <i>SLCO1B1</i> rs4149015 affect the PK profile of moxifloxacin, a key drug for MDR-TB. This study aimed to assess the genotype frequencies of <i>ABCB1</i> rs2032582 and...

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Bibliographic Details
Main Authors: Nurul Annisa, Nadiya N. Afifah, Prayudi Santoso, Vycke Yunivita, Lindsey H. M. te Brake, Rob E. Aarnoutse, Melisa I. Barliana, Rovina Ruslami
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Antibiotics
Subjects:
pharmacogenetics
pharmacokinetics
AUC<sub>0–24</sub>
C<sub>max</sub>
moxifloxacin
<i>ABCB1</i> rs2032582
Online Access:https://www.mdpi.com/2079-6382/14/2/204

Internet

https://www.mdpi.com/2079-6382/14/2/204

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