Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods

Encapsulation of Large-Size Plasmids in PLGA Nanoparticles for Gene Editing: Comparison of Three Different Synthesis Methods

The development of new gene-editing technologies has fostered the need for efficient and safe vectors capable of encapsulating large nucleic acids. In this work we evaluate the synthesis of large-size plasmid-loaded PLGA nanoparticles by double emulsion (considering batch ultrasound and microfluidic...

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Bibliographic Details
Main Authors: Tresa López-Royo, Víctor Sebastián, Laura Moreno-Martínez, Laura Uson, Cristina Yus, Teresa Alejo, Pilar Zaragoza, Rosario Osta, Manuel Arruebo, Raquel Manzano
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Nanomaterials
Subjects:
plasmid-loaded nanoparticles
PLGA
biodegradable polymer
large-size plasmid
DNA
double emulsion solvent evaporation
Online Access:https://www.mdpi.com/2079-4991/11/10/2723

Internet

https://www.mdpi.com/2079-4991/11/10/2723

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