CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells

CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells

There is an unmet need to discover suitable targets for CAR-T therapy in patients with acute myeloid leukemia (AML). Here the authors show that GRP78, a key regulator of the unfolded protein response, is highly expressed on the surface of primary AML blasts, but not on normal lymphocytes and hematop...

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Bibliographic Details
Main Authors: Nikhil Hebbar, Rebecca Epperly, Abishek Vaidya, Unmesha Thanekar, Sarah E. Moore, Masayuki Umeda, Jing Ma, Sagar L. Patil, Deanna Langfitt, Sujuan Huang, Cheng Cheng, Jeffery M. Klco, Stephen Gottschalk, M. Paulina Velasquez
Format: Article
Language:English
Published: Nature Portfolio 2022-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28243-6

Internet

https://doi.org/10.1038/s41467-022-28243-6

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