Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells

Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells

Development of resistance to currently available standard therapies in advanced prostate cancer (PCa) emphasizes the need for novel therapeutic options. Here, we report the synthesis of new hybrid molecules consisting of 2-chloroethylthio and 1,4-naphthoquinone pharmacophores and describe their acti...

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Bibliographic Details
Main Authors: Sergey A. Dyshlovoy, Dmitry N. Pelageev, Lea S. Jakob, Ksenia L. Borisova, Jessica Hauschild, Tobias Busenbender, Moritz Kaune, Ekaterina A. Khmelevskaya, Markus Graefen, Carsten Bokemeyer, Victor Ph. Anufriev, Gunhild von Amsberg
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
1,4-naphthoquinone
2-chloroethylthio
castration-resistant prostate cancer
ROS
apoptosis
mitochondria
Online Access:https://www.mdpi.com/1424-8247/14/10/949

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https://www.mdpi.com/1424-8247/14/10/949

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