Analysis of Integrin α<sub>IIb</sub> Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains

Analysis of Integrin α<sub>IIb</sub> Subunit Dynamics Reveals Long-Range Effects of Missense Mutations on Calf Domains

Integrin α<sub>IIb</sub>β<sub>3</sub>, a glycoprotein complex expressed at the platelet surface, is involved in platelet aggregation and contributes to primary haemostasis. Several integrin α<sub>IIb</sub>β<sub>3</sub> polymorphisms prevent the aggrega...

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Bibliographic Details
Main Authors: Sali Anies, Vincent Jallu, Julien Diharce, Tarun J. Narwani, Alexandre G. de Brevern
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
secondary structure
sequence–structure relationship
structural alphabet
bleeding disorder
flexibility
molecular dynamics
Online Access:https://www.mdpi.com/1422-0067/23/2/858

Internet

https://www.mdpi.com/1422-0067/23/2/858

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