Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility

Putative functional non-coding polymorphisms in SELP significantly modulate sP-selectin levels, arterial stiffness and type 2 diabetes mellitus susceptibility

Abstract Background P-selectin, encoded by SELP, has been implicated as an important molecule in the development of arterial stiffness, consequently leading to vascular complications in T2DM. SELP polymorphisms and increased levels of soluble P-selectin (sP-selectin) have been shown to be associated...

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Bibliographic Details
Main Authors: Raminderjit Kaur, Jatinder Singh, Rohit Kapoor, Manpreet Kaur
Format: Article
Language:English
Published: BMC 2020-05-01
Series:BMC Endocrine Disorders
Subjects:
Atherosclerosis
Haplotype
Pulse wave velocity
Selectin
SNP
Vascular risk
Online Access:http://link.springer.com/article/10.1186/s12902-020-00548-x

Internet

http://link.springer.com/article/10.1186/s12902-020-00548-x

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