Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity

Contribution of PGE2 EP1 receptor in hemin-induced neurotoxicity

Although hemin-mediated neurotoxicity has been linked to the production of free radicals and glutamate excitotoxicity, the role of the prostaglandin E2 (PGE2)-EP1 receptor remains unclear. Activation of the EP1 receptor in neurons results in increased intracellular calcium levels; therefore, we hypo...

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Bibliographic Details
Main Authors: Shekher eMohan, Alexander V. Glushakov, Alexander edeCurnou, Shuh eNarumiya, Sylvain eDoré
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-10-01
Series:Frontiers in Molecular Neuroscience
Subjects:
Calcium
Calcium Signaling
Heme
Hemin
Prostaglandins
Prostaglandins E
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00031/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnmol.2013.00031/full

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