The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b

The Deubiquitinase USP29 Promotes SARS-CoV-2 Virulence by Preventing Proteasome Degradation of ORF9b

ABSTRACT Ubiquitin signaling is essential for immunity to restrict pathogen proliferation. Due to its enormous impact on human health and the global economy, intensive efforts have been invested in studying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its interactions with hosts....

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Bibliographic Details
Main Authors: Wenying Gao, Liuli Wang, Xiaohui Ju, Simin Zhao, Zhaolong Li, Manman Su, Jiancheng Xu, Peihui Wang, Qiang Ding, Guoyue Lv, Wenyan Zhang
Format: Article
Language:English
Published: American Society for Microbiology 2022-06-01
Series:mBio
Subjects:
SARS-CoV-2
ORF9b
degradation
USP29
deubiquitination
Online Access:https://journals.asm.org/doi/10.1128/mbio.01300-22

Internet

https://journals.asm.org/doi/10.1128/mbio.01300-22

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