Hooked Up from a Distance: Charting Genome-Wide Long-Range Interaction Maps in Neural Cells Chromatin to Identify Novel Candidate Genes for Neurodevelopmental Disorders

Hooked Up from a Distance: Charting Genome-Wide Long-Range Interaction Maps in Neural Cells Chromatin to Identify Novel Candidate Genes for Neurodevelopmental Disorders

DNA sequence variants (single nucleotide polymorphisms or variants, SNPs/SNVs; copy number variants, CNVs) associated to neurodevelopmental disorders (NDD) and traits often map on putative transcriptional regulatory elements, including, in particular, enhancers. However, the genes controlled by thes...

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Bibliographic Details
Main Authors: Sara Mercurio, Giorgia Pozzolini, Roberta Baldi, Sara E. Barilà, Mattia Pitasi, Orazio Catona, Romina D’Aurizio, Silvia K. Nicolis
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
enhancers
chromatin
long-range interactions
DNA sequence variants
neurodevelopmental disorders (NDD)
CRISPR-Cas9
Online Access:https://www.mdpi.com/1422-0067/24/2/1164

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https://www.mdpi.com/1422-0067/24/2/1164

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