Phenotypic immune characterization of gastric and esophageal adenocarcinomas reveals profound immune suppression in esophageal tumor locations

Phenotypic immune characterization of gastric and esophageal adenocarcinomas reveals profound immune suppression in esophageal tumor locations

BackgroundTumors in the distal esophagus (EAC), gastro-esophageal junction including cardia (GEJAC), and stomach (GAC) develop in close proximity and show strong similarities on a molecular and cellular level. However, recent clinical data showed that the effectiveness of chemo-immunotherapy is limi...

Full description

Bibliographic Details
Main Authors: Tessa S. Groen-van Schooten, Micaela Harrasser, Jens Seidel, Emma N. Bos, Tania Fleitas, Monique van Mourik, Roos E. Pouw, Ruben S. A. Goedegebuure, Benthe H. Doeve, Jasper Sanders, Joris Bos, Mark I. van Berge Henegouwen, Victor L. J. L. Thijssen, Nicole C. T. van Grieken, Hanneke W. M. van Laarhoven, Tanja D. de Gruijl, Sarah Derks
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Immunology
Subjects:
tumor microenvironment
single cell flow cytometry
biomarkers
HER2
MSI
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1372272/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1372272/full

Similar Items