Therapeutic targeting of vimentin by ALD-R491 impacts multiple pathogenic processes to attenuate acute and chronic colitis in mice

Therapeutic targeting of vimentin by ALD-R491 impacts multiple pathogenic processes to attenuate acute and chronic colitis in mice

Background: Vimentin, an intermediate filament protein, crucially contributes to the pathogenesis of inflammatory bowel disease (IBD) by interacting with genetic risk factors, facilitating pathogen infection, and modulating both innate and adaptive immune responses. This study aimed to demonstrate p...

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Bibliographic Details
Main Authors: Jianping Wu, Xueting Wu, Cheng Cheng, Lu Liu, Le Xu, Zijing Xu, Shuaishuai Wang, Deebie Symmes, Lian Mo, Ruihuan Chen, Junfeng Zhang
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Vimentin targeting
ALD-R491
IBD
Treg/Th17
Gut microbiota
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223014464

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http://www.sciencedirect.com/science/article/pii/S0753332223014464

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