Methylation Profiling Defines an Extensive Field Defect in Histologically Normal Prostate Tissues Associated with Prostate Cancer

Prostate cancer (PCa) is typically found as a multifocal disease suggesting the potential for molecular defects within the morphologically normal tissue. The frequency and spatial extent of DNA methylation changes encompassing a potential field defect are unknown. A comparison of non-tumor-associate...

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Bibliographic Details
Main Authors: Bing Yang, Sachin Bhusari, Jessica Kueck, Pushpa Weeratunga, Jennifer Wagner, Glen Leverson, Wei Huang, David F. Jarrard
Format: Article
Language:English
Published: Elsevier 2013-04-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558613800474