Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

Differential polarization and the expression of efferocytosis receptor MerTK on M1 and M2 macrophages isolated from coronary artery disease patients

Abstract Background Differential polarization of macrophage into M1 and M2 mediates atherosclerotic plaque clearance through efferocytosis. Higher expression of Mer proto-oncogene tyrosine kinase (MerTK) on M2 macrophage helps in maintaining macrophage efferocytic efficiency. In healthy individuals,...

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Bibliographic Details
Main Authors: Fatin Najiah Mohd Idrus, Nurul Shuhadah Ahmad, Chee Hock Hoe, Maryam Azlan, Farisha Alia Norfuad, Zurkurnai Yusof, Wan Yus Haniff Wan Isa, Akbar Ali Mohamed Ali, Get Bee Yvonne-Tee
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Immunology
Subjects:
Cell surface differentiation marker
Coronary artery disease
Efferocytosis
Macrophage polarization
Mer proto-oncogene tyrosine kinase
Online Access:https://doi.org/10.1186/s12865-021-00410-2

Internet

https://doi.org/10.1186/s12865-021-00410-2

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