Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression

Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression

Abstract Background Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1α and HIF-2α, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade of PD-1 and its ligand PD-L1 reorganizes T-cell activity in tumor micr...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Hayriye Tatli Dogan, Merve Kiran, Burak Bilgin, Aydan Kiliçarslan, Mehmet Ali Nahit Sendur, Bülent Yalçin, Arslan Ardiçoglu, Ali Fuat Atmaca, Berrak Gumuskaya
Format: Artikel
Sprache:English
Veröffentlicht: BMC 2018-08-01
Schriftenreihe:Diagnostic Pathology
Schlagworte:
PD-L1
PD-1
HIF
Renal cell carcinoma
Online Zugang:http://link.springer.com/article/10.1186/s13000-018-0742-8

Online

http://link.springer.com/article/10.1186/s13000-018-0742-8

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