A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth

A Small-Scale shRNA Screen in Primary Mouse Macrophages Identifies a Role for the Rab GTPase Rab1b in Controlling Salmonella Typhi Growth

Salmonella Typhi is a human-restricted bacterial pathogen that causes typhoid fever, a life-threatening systemic infection. A fundamental aspect of S. Typhi pathogenesis is its ability to survive in human macrophages but not in macrophages from other animals (i.e. mice). Despite the importance of ma...

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Bibliographic Details
Main Authors: Virtu Solano-Collado, Rosa Angela Colamarino, David A. Calderwood, Massimiliano Baldassarre, Stefania Spanò
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
host-defense
Salmonella Typhi
Rab GTPases
Rab1b
shRNA screen
macrophages
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.660689/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2021.660689/full

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