CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

CCL5 Release by CCR9+ CD8 T Cells: A Potential Contributor to Immunopathology of Primary Sjögren’s Syndrome

IntroductionIncreased CCL5 expression and CD8 T cells have been shown to be pivotal regulators of immunopathology in primary Sjögren’s syndrome (pSS) and pSS-like disease. Increased CCL5 expression by CCR9+ CD4 T cells has previously been implicated as a contributor to immunopathology in pSS. The ro...

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Bibliographic Details
Main Authors: Anneline C. Hinrichs, Sofie L. M. Blokland, Aike A. Kruize, Floris P. J. Lafeber, Helen L. Leavis, Joel A. G. van Roon
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Immunology
Subjects:
primary Sjögren’s syndrome (pSS)
CCR9+ T cells
autoimmunity
CCL5
CD8 T cells
transcriptomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.887972/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.887972/full

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