The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

The homodimer interfaces of costimulatory receptors B7 and CD28 control their engagement and pro-inflammatory signaling

Abstract Background The inflammatory response is indispensable for protective immunity, yet microbial pathogens often trigger an excessive response, ‘cytokine storm’, harmful to the host. Full T-cell activation requires interaction of costimulatory receptors B7-1(CD80) and B7-2(CD86) expressed on an...

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Bibliographic Details
Main Authors: Andrey Popugailo, Ziv Rotfogel, Michal Levy, Orli Turgeman, Dalia Hillman, Revital Levy, Gila Arad, Tomer Shpilka, Raymond Kaempfer
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Biomedical Science
Subjects:
Inflammatory cytokine storm
Pro-inflammatory signaling
Costimulatory receptors B7 and CD28
Control of B7/CD28 receptor engagement
Receptor homodimer interface mimetic peptides
Regulation of B7/CD28 signaling
Online Access:https://doi.org/10.1186/s12929-023-00941-3

Internet

https://doi.org/10.1186/s12929-023-00941-3

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