Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model

Abstract Background Premature ovarian failure (POF) is one of the leading causes of female infertility and is accompanied by abnormal endocrine, seriously affecting female quality of life. Previous studies have demonstrated that mesenchymal stem cells (MSCs) transplantation is a promising therapeuti...

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Bibliographic Details
Main Authors: Wenjie Dai, Hong Yang, Bo Xu, Tiantian He, Ling Liu, Xiaoqian Ma, Jiaxue Ma, Guoqin Yang, Rui Si, Xiuying Pei, Xing Du, Xufeng Fu
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Ovarian Research
Subjects:
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs)
Premature ovarian failure
Ovarian granulosa cells
Excessive autophagy
PI3K/AKT/mTOR
Online Access:https://doi.org/10.1186/s13048-023-01278-z

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https://doi.org/10.1186/s13048-023-01278-z

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