Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration

Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration

The nucleus pulposus (NP), a heterogeneous tissue, is an essential functional component of the intervertebral disc. However, NP cell development route and regulation mechanism in intervertebral disc degeneration (IVDD) remain unknown. Here, we performed single-cell RNA sequencing of six NP samples w...

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Bibliographic Details
Main Authors: Shuo Han, Yiran Zhang, Xianjuan Zhang, Hao Zhang, Shengwei Meng, Meng Kong, Xiaojie Liu, Xuexiao Ma
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
single-cell RNA sequencing
intervertebral disc degeneration
nucleus pulposus
chondrocyte
differentiation and regulation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.824771/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.824771/full

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