Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration

Single-Cell RNA Sequencing of the Nucleus Pulposus Reveals Chondrocyte Differentiation and Regulation in Intervertebral Disc Degeneration

The nucleus pulposus (NP), a heterogeneous tissue, is an essential functional component of the intervertebral disc. However, NP cell development route and regulation mechanism in intervertebral disc degeneration (IVDD) remain unknown. Here, we performed single-cell RNA sequencing of six NP samples w...

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Bibliographic Details
Main Authors:	Shuo Han, Yiran Zhang, Xianjuan Zhang, Hao Zhang, Shengwei Meng, Meng Kong, Xiaojie Liu, Xuexiao Ma
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-02-01
Series:	Frontiers in Cell and Developmental Biology
Subjects:	single-cell RNA sequencing intervertebral disc degeneration nucleus pulposus chondrocyte differentiation and regulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fcell.2022.824771/full

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