Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Uses the VraSR Regulatory System to Modulate Autophagy for Increased Intracellular Survival in Macrophage-Like Cell Line RAW264.7

Heterogeneous Vancomycin-Intermediate Staphylococcus aureus Uses the VraSR Regulatory System to Modulate Autophagy for Increased Intracellular Survival in Macrophage-Like Cell Line RAW264.7

The VraSR two-component system is a vancomycin resistance-associated sensor/regulator that is upregulated in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) strains. VISA/hVISA show reduced susceptibility to vancomycin and an increased ability to evade host immune...

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Bibliographic Details
Main Authors: Yuanyuan Dai, Caihong Gao, Li Chen, Wenjiao Chang, Wenwei Yu, Xiaoling Ma, Jiabin Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Microbiology
Subjects:
Staphylococcus aureus
autophagy
VraSR
regulation
macrophage
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.01222/full

Internet

https://www.frontiersin.org/article/10.3389/fmicb.2019.01222/full

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