Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

Cryo-EM structure of the Plasmodium falciparum 80S ribosome bound to the anti-protozoan drug emetine

Malaria inflicts an enormous burden on global human health. The emergence of parasite resistance to front-line drugs has prompted a renewed focus on the repositioning of clinically approved drugs as potential anti-malarial therapies. Antibiotics that inhibit protein translation are promising candida...

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Bibliographic Details
Main Authors: Wilson Wong, Xiao-chen Bai, Alan Brown, Israel S Fernandez, Eric Hanssen, Melanie Condron, Yan Hong Tan, Jake Baum, Sjors HW Scheres
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-06-01
Series:eLife
Subjects:
malaria
Plasmodium falciparum
ribosome
drug development
cryo-EM
Online Access:https://elifesciences.org/articles/03080

Internet

https://elifesciences.org/articles/03080

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