C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment
The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase (cGAS), which triggers robust activation of the innate immune...
Main Authors: | , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
KeAi Communications Co., Ltd.
2023-11-01
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Series: | Bioactive Materials |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2452199X23002074 |