C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell death. Cell free-double strand DNA (dsDNA) segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase (cGAS), which triggers robust activation of the innate immune...

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Bibliographic Details
Main Authors: Zhixin Zhu, Haipeng Lu, Lulu Jin, Yong Gao, Zhefeng Qian, Pan Lu, Weijun Tong, Pik Kwan Lo, Zhengwei Mao, Haifei Shi
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2023-11-01
Series:Bioactive Materials
Subjects:
Ischemic stroke
Ce-based nano-nuclease
The cGAS-STING signaling pathway
Anti-inflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X23002074

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http://www.sciencedirect.com/science/article/pii/S2452199X23002074

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