RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition

RAF inhibitors promote RAS-RAF interaction by allosterically disrupting RAF autoinhibition

RAF family kinases transmit signals from activated RAS at the plasma membrane to downstream kinases to control cell proliferation, differentiation and survival. Here the authors shed light on the molecular mechanisms whereby small molecule RAF inhibitors induce RAS-RAF association and paradoxical RA...

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Sonraí bibleagrafaíochta
Príomhchruthaitheoirí: Ting Jin, Hugo Lavoie, Malha Sahmi, Maud David, Christine Hilt, Amy Hammell, Marc Therrien
Formáid: Alt
Teanga:English
Foilsithe / Cruthaithe: Nature Portfolio 2017-10-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-017-01274-0

Ar líne

https://doi.org/10.1038/s41467-017-01274-0

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