Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium‐Dependent Hyperpolarization–Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension

Chronic Hypoxia Decreases Endothelial Connexin 40, Attenuates Endothelium‐Dependent Hyperpolarization–Mediated Relaxation in Small Distal Pulmonary Arteries, and Leads to Pulmonary Hypertension

Background Abnormal endothelial function in the lungs is implicated in the development of pulmonary hypertension; however, there is little information about the difference of endothelial function between small distal pulmonary artery (PA) and large proximal PA and their contribution to the developme...

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Bibliographic Details
Main Authors: Rui Si, Qian Zhang, Jody Tori O. Cabrera, Qiuyu Zheng, Atsumi Tsuji‐Hosokawa, Makiko Watanabe, Susumu Hosokawa, Mingmei Xiong, Pritesh P. Jain, Anthony W. Ashton, Jason X.‐J. Yuan, Jian Wang, Ayako Makino
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiovascular disease
connexin
endothelial cell
gap junction
hypoxia‐induced pulmonary hypertension
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.120.018327

Internet

https://www.ahajournals.org/doi/10.1161/JAHA.120.018327

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