Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model

Characterization of the spectrum of trivalent VAV1‐mutation‐driven tumours using a gene‐edited mouse model

Mutations in the VAV1 guanine nucleotide exchange factor 1 have been recently found in peripheral T cell lymphoma and nonsmall‐cell lung cancer (NSCLC). To understand their pathogenic potential, we generated a gene‐edited mouse model that expresses a VAV1 mutant protein that recapitulates the signal...

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Bibliographic Details
Main Authors: Javier Robles‐Valero, Lucía Fernández‐Nevado, Myriam Cuadrado, Luis Francisco Lorenzo‐Martín, Isabel Fernández‐Pisonero, Antonio Abad, Esther Redín, Luis Montuenga, Dionisio Martín‐Zanca, Anna Bigas, Moisés Mallo, Mercedes Dosil, Xosé R. Bustelo
Format: Article
Language:English
Published: Wiley 2022-10-01
Series:Molecular Oncology
Subjects:
angioimmunoblastic T cell lymphoma
follicular helper T cells
nonsmall‐cell lung cancer
peripheral T cell lymphoma
RAC1
TP53
Online Access:https://doi.org/10.1002/1878-0261.13295

Internet

https://doi.org/10.1002/1878-0261.13295

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