MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma

MYC dependency in GLS1 and NAMPT is a therapeutic vulnerability in multiple myeloma

Summary: Multiple myeloma (MM) is an incurable hematological malignancy in which MYC alterations contribute to the malignant phenotype. Nevertheless, MYC lacks therapeutic druggability. Here, we leveraged large-scale loss-of-function screens and conducted a small molecule screen to identify genes an...

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Bibliographic Details
Main Authors: Lama Hasan Bou Issa, Léa Fléchon, William Laine, Aicha Ouelkdite, Silvia Gaggero, Adeline Cozzani, Remi Tilmont, Paul Chauvet, Nicolas Gower, Romanos Sklavenitis-Pistofidis, Carine Brinster, Xavier Thuru, Yasmine Touil, Bruno Quesnel, Suman Mitra, Irene M. Ghobrial, Jérôme Kluza, Salomon Manier
Format: Article
Language:English
Published: Elsevier 2024-04-01
Series:iScience
Subjects:
Cancer
Metabolomics
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224006382

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http://www.sciencedirect.com/science/article/pii/S2589004224006382

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