A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

A Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication

Abstract The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. Despite its significance, the precise regulatory mechanisms underlying its functio...

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Bibliographic Details
Main Authors: Yuzheng Zhou, Zongpeng Chen, Sijie Liu, Sixu Liu, Yujie Liao, Ashuai Du, Zijun Dong, Yongxing Zhang, Xuan Chen, Siyi Tao, Xin Wu, Aroona Razzaq, Gang Xu, De-an Tan, Shanni Li, Youwen Deng, Jian Peng, Shuyan Dai, Xu Deng, Xianwen Zhang, Taijiao Jiang, Zheng Zhang, Gong Cheng, Jincun Zhao, Zanxian Xia
Format: Article
Language:English
Published: Nature Publishing Group 2024-06-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-024-01874-5

Internet

https://doi.org/10.1038/s41392-024-01874-5

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