HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

HSP90AA1-mediated autophagy promotes drug resistance in osteosarcoma

Abstract Background Osteosarcoma is the most common primary bone tumor in children and adolescents. Unfortunately, osteosarcoma treatments often fail due to the development of chemoresistance, of which the underlying molecular mechanisms still remain unclear. In this study, we demonstrated that HSP9...

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Bibliographic Details
Main Authors: Xin Xiao, Wei Wang, Yuqian Li, Di Yang, Xiaokang Li, Chao Shen, Yan Liu, Xianzhu Ke, Shuo Guo, Zheng Guo
Format: Article
Language:English
Published: BMC 2018-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Autophagy
HSP90AA1
Chemoresistance
Apoptosis
Osteosarcoma
Online Access:http://link.springer.com/article/10.1186/s13046-018-0880-6

Internet

http://link.springer.com/article/10.1186/s13046-018-0880-6

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