Zebrafish <i>mafbb</i> Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients

Zebrafish <i>mafbb</i> Mutants Display Osteoclast Over-Activation and Bone Deformity Resembling Osteolysis in MCTO Patients

Multicentric carpotarsal osteolysis (MCTO) is a rare skeletal dysplasia with osteolysis at the carpal and tarsal bones. Heterozygous missense mutations in the transcription factor MAFB are found in patients with MCTO. MAFB is reported to negatively regulate osteoclastogenesis in vitro. However, the...

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Bibliographic Details
Main Authors: Yujie Han, Weihao Shao, Dan Zhong, Cui Ma, Xiaona Wei, Abrar Ahmed, Tingting Yu, Wei Jing, Lili Jing
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Biomolecules
Subjects:
MAFB
Multicentric Carpotarsal Osteolysis (MCTO)
osteoclasts
macrophage and monocytes
zebrafish
Online Access:https://www.mdpi.com/2218-273X/11/3/480

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https://www.mdpi.com/2218-273X/11/3/480

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