Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

Presynaptic Rac1 controls synaptic strength through the regulation of synaptic vesicle priming

Synapses contain a limited number of synaptic vesicles (SVs) that are released in response to action potentials (APs). Therefore, sustaining synaptic transmission over a wide range of AP firing rates and timescales depends on SV release and replenishment. Although actin dynamics impact synaptic tran...

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Bibliographic Details
Main Authors: Christian Keine, Mohammed Al-Yaari, Tamara Radulovic, Connon I Thomas, Paula Valino Ramos, Debbie Guerrero-Given, Mrinalini Ranjan, Holger Taschenberger, Naomi Kamasawa, Samuel M Young Jr
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
rac1
actin cytoskeleton
auditory brainstem
synaptic plasticity
synaptic transmission
synaptic vesicle replenishment
Online Access:https://elifesciences.org/articles/81505

Internet

https://elifesciences.org/articles/81505

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