Intranasal Delivery of Gene-Edited Microglial Exosomes Improves Neurological Outcomes after Intracerebral Hemorrhage by Regulating Neuroinflammation

Intranasal Delivery of Gene-Edited Microglial Exosomes Improves Neurological Outcomes after Intracerebral Hemorrhage by Regulating Neuroinflammation

Neural inflammatory response is a crucial pathological change in intracerebral hemorrhage (ICH) which accelerates the formation of perihematomal edema and aggravates neural cell death. Although surgical and drug treatments for ICH have advanced rapidly in recent years, therapeutic strategies that ta...

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Bibliographic Details
Main Authors: Mengtian Guo, Xintong Ge, Conglin Wang, Zhenyu Yin, Zexi Jia, Tianpeng Hu, Meimei Li, Dong Wang, Zhaoli Han, Lu Wang, Xiangyang Xiong, Fanglian Chen, Ping Lei
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Brain Sciences
Subjects:
intranasal delivery
miRNA-124
microglia
exosome
intracerebral hemorrhage
neuroinflammation
Online Access:https://www.mdpi.com/2076-3425/13/4/639

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https://www.mdpi.com/2076-3425/13/4/639

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