Discovery of C-12 dithiocarbamate andrographolide analogues as inhibitors of SARS-CoV-2 main protease: In vitro and in silico studies

Discovery of C-12 dithiocarbamate andrographolide analogues as inhibitors of SARS-CoV-2 main protease: In vitro and in silico studies

A global crisis of coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has impacted millions of people’s lives throughout the world. In parallel to vaccine development, identifying potential antiviral agents against SARS-CoV-2 has becom...

Full description

Bibliographic Details
Main Authors: Bodee Nutho, Patcharin Wilasluck, Peerapon Deetanya, Kittikhun Wangkanont, Patcharee Arsakhant, Rungnapha Saeeng, Thanyada Rungrotmongkol
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
COVID-19
SARS-CoV-2 main protease
Andrographolide analogues
Molecular docking
MD simulations
Enzyme-based assay
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022002094

Internet

http://www.sciencedirect.com/science/article/pii/S2001037022002094

Similar Items