Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship

Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: Structural insights in their binding mode and structure-activity relationship

Context: Valeriana pavonii Poepp. & Endl. (Caprifoliaceae), is a plant used in traditional medicine as a tranquilizer in Colombia. Valerian extracts have been widely used since ancient times for their sedative and anxiolytic properties; however, the way its active metabolites, including iridoids...

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Bibliographic Details
Main Authors: Sara E. Giraldo, Mauricio Bedoya, Carlos Peña-Varas, Paula A. Santana, Isabel L. Bazzocchi, Ignacio A. Jiménez, Mariel Marder, Nadezdha E. Vergel, Mario F. Guerrero, David Ramírez
Format: Article
Language:English
Published: GarVal Editorial Ltda. 2023-05-01
Series:Journal of Pharmacy & Pharmacognosy Research
Subjects:
ensemble molecular docking
iridoids
gabaa modulators
gabaa receptor
valerian
Online Access:https://jppres.com/jppres/pdf/vol11/jppres22.1570_11.3.367.pdf

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https://jppres.com/jppres/pdf/vol11/jppres22.1570_11.3.367.pdf

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