Wnt antagonism without TGFβ induces rapid MSC chondrogenesis via increasing AJ interactions and restricting lineage commitment

Wnt antagonism without TGFβ induces rapid MSC chondrogenesis via increasing AJ interactions and restricting lineage commitment

Summary: Human mesenchymal stem cells (MSCs) remain one of the best cell sources for cartilage, a tissue without regenerative capacity. However, MSC chondrogenesis is commonly induced through TGFβ, a pleomorphic growth factor without specificity for this lineage. Using tissue- and induced pluripoten...

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Bibliographic Details
Main Authors: Chen-Chan Hsieh, B. Linju Yen, Chia-Chi Chang, Pei-Ju Hsu, Yu-Wei Lee, Men-Luh Yen, Shaw-Fang Yet, Linyi Chen
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Bioengineering
Biological sciences
Molecular medicine
Tissue engineering
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019861

Internet

http://www.sciencedirect.com/science/article/pii/S2589004222019861

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