Identification of 2,4-Diaminoquinazoline Derivative as a Potential Small-Molecule Inhibitor against Chikungunya and Ross River Viruses

Identification of 2,4-Diaminoquinazoline Derivative as a Potential Small-Molecule Inhibitor against Chikungunya and Ross River Viruses

Alphaviruses are serious zoonotic threats responsible for significant morbidity, causing arthritis or encephalitis. So far, no licensed drugs or vaccines are available to combat alphaviral infections. About 300,000 chikungunya virus (CHIKV) infections have been reported in 2023, with more than 300 d...

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Bibliographic Details
Main Authors: Amrita Saha, Badri Narayan Acharya, Manmohan Parida, Nandita Saxena, Jaya Rajaiya, Paban Kumar Dash
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Viruses
Subjects:
chikungunya virus
antiviral drug
2,4-diaminoquinazoline derivative
Ross River virus
pan-alphavirus inhibitor
drug screening
Online Access:https://www.mdpi.com/1999-4915/15/11/2194

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https://www.mdpi.com/1999-4915/15/11/2194

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