TR-57 Treatment of SUM159 Cells Induces Mitochondrial Dysfunction without Affecting Membrane Potential

TR-57 Treatment of SUM159 Cells Induces Mitochondrial Dysfunction without Affecting Membrane Potential

Recent works identified ClpXP, mitochondrial caseinolytic protease, as the only target of imipridones, a new class of antitumor agents. Our study of the mechanism of imipridone derivative TR-57 action in SUM159 human breast cancer cells demonstrated mitochondrial fragmentation, degradation of mitoch...

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Bibliographic Details
Main Authors: Artem Mishukov, Ekaterina Mndlyan, Alexey V. Berezhnov, Margarita Kobyakova, Yana Lomovskaya, Ekhson Holmuhamedov, Irina Odinokova
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
TR-57
SUM159 TNBC cells
respiratory complexes: mitochondrial membrane potential
FoF<sub>1</sub>-ATPase
IF1
calcium-regulated mitochondrial ATP-Mg/Pi carrier
Online Access:https://www.mdpi.com/1422-0067/25/2/1193

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https://www.mdpi.com/1422-0067/25/2/1193

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