Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

Modulation of Spatial Memory Deficit and Hyperactivity in Dopamine Transporter Knockout Rats via α2A-Adrenoceptors

Attention deficit hyperactivity disorder (ADHD) is manifested by a specific set of behavioral deficits such as hyperactivity, impulsivity, and inattention. The dopamine neurotransmitter system is postulated to be involved in the pathogenesis of ADHD. Guanfacine, a selective α2A-adrenoceptor agonist,...

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Bibliographic Details
Main Authors: Natalia Kurzina, Anastasia Belskaya, Arina Gromova, Alla Ignashchenkova, Raul R. Gainetdinov, Anna Volnova
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Psychiatry
Subjects:
dopamine transporter knockout (DAT-KO) rats
ADHD model
norepinephrine (NE)
dopamine (DA)
α2A-adrenoceptors
Guanfacine (GF)
Online Access:https://www.frontiersin.org/articles/10.3389/fpsyt.2022.851296/full

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https://www.frontiersin.org/articles/10.3389/fpsyt.2022.851296/full

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