Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

Spatio-temporal regulation of calpain activity after experimental myocardial infarction in vivo

Background: Calpains are calcium activated cysteine proteases that play a pivotal role in the pathophysiology of cardiac remodeling. Methods: Here, we performed left anterior descending coronary artery ligation in rats as a model for ischemic systolic heart failure and examined the time- and region-...

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Bibliographic Details
Main Authors: Kun Zhang, Melissa M. Cremers, Stephan Wiedemann, David M. Poitz, Christian Pfluecke, Frank R. Heinzel, Burkert Pieske, Volker Adams, Antje Schauer, Robert Winzer, Ruth H. Strasser, Axel Linke, Silvio Quick, Felix M. Heidrich
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
Experimental myocardial infarction
Calcium
Calpain
Calpain-1
Calpain-2
Calpastatin
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580821002569

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http://www.sciencedirect.com/science/article/pii/S2405580821002569

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