Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma

Genomic Analysis Revealed New Oncogenic Signatures in TP53-Mutant Hepatocellular Carcinoma

The TP53 gene is the most commonly mutated gene in human cancers and mutations in TP53 have been shown to have either gain-of-function or loss-of-function effects. Using the data generated by The Cancer Genome Atlas, we sought to define the spectrum of TP53 mutations in hepatocellular carcinomas (HC...

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Bibliographic Details
Main Authors: Venkatesh Kancherla, Samir Abdullazade, Matthias S. Matter, Manuela Lanzafame, Luca Quagliata, Guglielmo Roma, Yujin Hoshida, Luigi M. Terracciano, Charlotte K. Y. Ng, Salvatore Piscuoglio
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-02-01
Series:Frontiers in Genetics
Subjects:
TP53 mutations
somatic mutations
copy number alterations
mutational signature
oncogenic signature
Online Access:http://journal.frontiersin.org/article/10.3389/fgene.2018.00002/full

Internet

http://journal.frontiersin.org/article/10.3389/fgene.2018.00002/full

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