Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa

Unexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa

Abstract Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gene predispose to a lower BMI. In individuals with reduced body weight, we thus e...

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Bibliographic Details
Main Authors: Luisa Sophie Rajcsanyi, Yiran Zheng, Beate Herpertz-Dahlmann, Jochen Seitz, Martina de Zwaan, Wolfgang Herzog, Stefan Ehrlich, Stephan Zipfel, Katrin Giel, Karin Egberts, Roland Burghardt, Manuel Föcker, Jochen Antel, Pamela Fischer-Posovszky, Johannes Hebebrand, Anke Hinney
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-57517-w

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https://doi.org/10.1038/s41598-024-57517-w

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