Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

Upon target RNA recognition, type III CRISPR-Cas systems produce cyclic oligoadenylates that activate effectors such as Csm6 ribonucleases. Here, Garcia-Doval et al. show that Enteroccocus italicus Csm6 degrades its cyclic hexa-AMP activator, and report the crystal structure of the protein bound to...

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Bibliographic Details
Main Authors: Carmela Garcia-Doval, Frank Schwede, Christian Berk, Jakob T. Rostøl, Ole Niewoehner, Oliver Tejero, Jonathan Hall, Luciano A. Marraffini, Martin Jinek
Format: Article
Language:English
Published: Nature Portfolio 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15334-5

Internet

https://doi.org/10.1038/s41467-020-15334-5

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