ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation

ATG7 upregulation contributes to malignant transformation of human bronchial epithelial cells by B[a]PDE via DNMT3B protein degradation and miR-494 promoter methylation

Lung cancer primarily arises from exposure to various environmental factors, particularly airborne pollutants. Among the various lung carcinogens, benzo(a)pyrene and its metabolite B[a]PDE are the strongest ones that actively contribute to lung cancer development. ATG7 is an E1-like activating enzym...

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Bibliographic Details
Main Authors: Zhongxian Tian, Xiaohui Hua, Junlan Zhu, Peiwei Li, Ruifan Chen, Xin Li, Tengda Li, Chengfan Zhou, Chuanshu Huang
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Ecotoxicology and Environmental Safety
Subjects:
B[a]PDE
ATG7
Autophagy
DNMT3B
Lung carcinogenesis
MiR-494
Online Access:http://www.sciencedirect.com/science/article/pii/S0147651323007777

Internet

http://www.sciencedirect.com/science/article/pii/S0147651323007777

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