The transcriptome landscape of 3D-cultured placental trophoblasts reveals activation of TLR2 and TLR3/7 in response to low Trypanosoma cruzi parasite exposure

The transcriptome landscape of 3D-cultured placental trophoblasts reveals activation of TLR2 and TLR3/7 in response to low Trypanosoma cruzi parasite exposure

Vertical transmission of Trypanosoma cruzi (T. cruzi) become a globalized health problem accounting for 22% of new cases of Chagas disease (CD). Congenital infection is now considered the main route of CD spread in non-endemic countries where no routine disease testing of pregnant women is implement...

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Bibliographic Details
Main Authors: Erica Silberstein, Charles C. Chung, Alain Debrabant
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Microbiology
Subjects:
congenital Chagas disease
Trypanosoma cruzi
3D-trophoblasts
resistance to infection
transcriptome analysis
Toll-like receptors
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1256385/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1256385/full

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