NOX4 Mediates <i>Pseudomonas aeruginosa</i>-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium

NOX4 Mediates <i>Pseudomonas aeruginosa</i>-Induced Nuclear Reactive Oxygen Species Generation and Chromatin Remodeling in Lung Epithelium

<i>Pseudomonas aeruginosa</i> (<i>PA</i>) infection increases reactive oxygen species (ROS), and earlier, we have shown a role for NADPH oxidase-derived ROS in <i>PA</i>-mediated lung inflammation and injury. Here, we show a role for the lung epithelial cell (LEpC...

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Bibliographic Details
Main Authors: Panfeng Fu, Ramaswamy Ramchandran, Tara Sudhadevi, Prasanth P. K. Kumar, Yashaswin Krishnan, Yuru Liu, Yutong Zhao, Narasimham L. Parinandi, Anantha Harijith, Junichi Sadoshima, Viswanathan Natarajan
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Antioxidants
Subjects:
<i>Pseudomonas aeruginosa</i> infection
NOX4
nuclear ROS
histone acetylation
HDAC1/2 oxidation
lung epithelium
Online Access:https://www.mdpi.com/2076-3921/10/3/477

Internet

https://www.mdpi.com/2076-3921/10/3/477

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