Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

Trimethylamine N-Oxide (TMAO) Inducing Endothelial Injury: UPLC-MS/MS-Based Quantification and the Activation of Cathepsin B-Mediated NLRP3 Inflammasome

TMAO is a new risk biomarker for cardiovascular disease. With trimethylammonium as its main chemical skeleton, TMAO is structurally similar to many endogenous metabolites, such as acetylcholine, carnitine, phosphorylcholine, etc. The mechanism of TMAO on the pathological process of CVD is still uncl...

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Bibliographic Details
Main Authors: Dongyu Lei, Wenbo Yu, Yi Liu, Yujie Jiang, Xiaohui Li, Jing Lv, Ying Li
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Molecules
Subjects:
Trimethylamine-N-Oxide
UPLC-MS/MS
endothelialinjury
NLRP3 inflammasome
Cathepsin B
Online Access:https://www.mdpi.com/1420-3049/28/9/3817

Internet

https://www.mdpi.com/1420-3049/28/9/3817

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