The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation

The Histone Demethylase Inhibitor GSK-J4 Is a Therapeutic Target for the Kidney Fibrosis of Diabetic Kidney Disease via DKK1 Modulation

Diabetic kidney disease (DKD) can cause inflammation and fibrosis, in addition to being the main complication of diabetes. Among many factors, epigenetic alterations in aberrant histone modifications play a key role in causing DKD. In this study, the mechanism of GSK-J4, a histone demethylase KDM6A...

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Bibliographic Details
Main Authors: Peir-Haur Hung, Yung-Chien Hsu, Tsung-Hsien Chen, Cheng Ho, Chun-Liang Lin
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:International Journal of Molecular Sciences
Subjects:
diabetic kidney disease
streptozotocin-induced diabetic mice
histone demethylase
fibrosis
inflammation
DKK1
Online Access:https://www.mdpi.com/1422-0067/23/16/9407

Internet

https://www.mdpi.com/1422-0067/23/16/9407

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